Kai Breuhahn Selected Research

Karyopherins (Importin)

11/2019	Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
4/2016	Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).
4/2016	Cellular apoptosis susceptibility (CAS) is overexpressed in thyroid carcinoma and maintains tumor cell growth: A potential link to the BRAFV600E mutation.
9/2014	Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.

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Kai Breuhahn Research Topics

Disease

62	Neoplasms (Cancer) 03/2024 - 10/2002
49	Hepatocellular Carcinoma (Hepatoma) 04/2024 - 10/2002
16	Liver Neoplasms (Liver Cancer) 04/2024 - 10/2009
10	Carcinogenesis 01/2023 - 10/2003
6	Neoplasm Metastasis (Metastasis) 03/2024 - 03/2010
5	Inflammation (Inflammations) 03/2024 - 09/2004
4	Liver Diseases (Liver Disease) 01/2019 - 01/2006
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2017 - 03/2009
4	Carcinoma (Carcinomatosis) 03/2010 - 01/2006
3	Cholangiocarcinoma 05/2024 - 01/2006
3	Liver Cell Adenoma (Hepatocellular Adenoma) 12/2022 - 03/2010
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 07/2016
2	Adenocarcinoma 05/2024 - 03/2009
2	Infections 04/2024 - 09/2006
2	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2022 - 06/2013
2	Adenoma (Adenomas) 12/2017 - 03/2010
2	Lymphoma (Lymphomas) 07/2016 - 08/2013
1	Hypercholesterolemia 03/2024
1	Avian Reticuloendotheliosis 11/2023
1	Colonic Neoplasms (Colon Cancer) 01/2023
1	Tics (Tic) 01/2022
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019
1	Lymphatic Metastasis 01/2018
1	Adenocarcinoma of Lung 01/2018
1	Mucinous Adenocarcinoma (Mucinous Carcinoma) 12/2017
1	Lung Neoplasms (Lung Cancer) 01/2017
1	Acute-Phase Reaction 01/2017
1	Chromosomal Instability (Chromosome Stability) 01/2017
1	Necrosis 01/2017

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 04/2024 - 09/2006
11	Messenger RNA (mRNA)IBA 01/2023 - 12/2004
8	Carrier Proteins (Binding Protein)IBA 01/2018 - 11/2007
6	Phosphotransferases (Kinase)IBA 11/2023 - 03/2008
5	Sorafenib (BAY 43-9006)FDA Link 03/2024 - 10/2013
5	Transcription Factors (Transcription Factor)IBA 03/2024 - 07/2012
5	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2018 - 09/2004
5	ElementsIBA 03/2016 - 03/2009
4	StathminIBA 11/2019 - 09/2007
4	Karyopherins (Importin)IBA 11/2019 - 09/2014
4	Small Interfering RNA (siRNA)IBA 01/2017 - 09/2007
4	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 03/2010 - 10/2002
3	TEA Domain Transcription FactorsIBA 03/2024 - 01/2017
3	CateninsIBA 01/2023 - 01/2019
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 03/2010
3	MicroRNAs (MicroRNA)IBA 01/2018 - 08/2016
3	LigandsIBA 07/2016 - 06/2013
3	Insulin-Like PeptidesIBA 05/2014 - 03/2008
3	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 03/2010 - 10/2002
2	Cadherins (E-Cadherin)IBA 12/2022 - 10/2003
2	Interleukin-6 (Interleukin 6)IBA 02/2022 - 01/2016
2	Epithelial Cell Adhesion MoleculeIBA 01/2022 - 01/2006
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2022 - 03/2016
2	Transcriptional Coactivator with PDZ-Binding Motif ProteinsIBA 10/2021 - 01/2020
2	Transcription Factor 4IBA 12/2020 - 01/2017
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2020 - 01/2017
2	Nuclear Pore Complex Proteins (Nucleoporins)IBA 01/2019 - 09/2006
2	Protein Isoforms (Isoforms)IBA 03/2016 - 10/2014
2	Sirolimus (Rapamycin)FDA Link 03/2016 - 08/2009
2	poly-U binding splicing factor 60KDaIBA 11/2015 - 10/2014
2	DNA (Deoxyribonucleic Acid)IBA 11/2015 - 09/2007
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 05/2014 - 11/2013
2	Transforming Growth Factor beta (TGF-beta)IBA 02/2014 - 12/2004
2	Insulin (Novolin)FDA Link 10/2013 - 07/2012
2	Cytostatic AgentsIBA 01/2013 - 09/2007
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 11/2012 - 11/2011
2	UbiquitinIBA 11/2012 - 11/2011
2	Ligases (Synthetase)IBA 11/2012 - 11/2011
2	Complementary DNA (cDNA)IBA 02/2009 - 09/2004
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 07/2006 - 07/2004
1	C-Reactive ProteinIBA 05/2024
1	AlbuminsIBA 05/2024
1	Actin Depolymerizing Factors (Cofilins)IBA 04/2024
1	PaxillinIBA 04/2024
1	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 04/2024
1	CholesterolIBA 03/2024
1	Apolipoproteins E (ApoE)IBA 03/2024
1	VinculinIBA 12/2022
1	gamma Catenin (Plakoglobin)IBA 12/2022
1	Histone DemethylasesIBA 01/2022
1	Untranslated RNA (Noncoding RNA)IBA 01/2022
1	Histones (Histone)IBA 01/2022
1	Competitive Endogenous RNAIBA 01/2022
1	OsteopontinIBA 12/2020
1	Plasminogen Activator Inhibitor 1IBA 10/2020
1	CytokinesIBA 10/2020
1	ChemokinesIBA 10/2020
1	MucinsIBA 12/2017
1	Potassium Iodide (Pima)FDA Link 12/2017
1	Urethane (Ethyl Carbamate)IBA 12/2017
1	GMP synthase (glutamine-hydrolyzing)IBA 02/2017
1	guanosine 5'-monophosphorothioateIBA 02/2017
1	Epidermal Growth Factor (EGF)IBA 01/2017
1	Thiostrepton (Gargon)IBA 01/2017
1	Verteporfin (Visudyne)FDA Link 01/2017
1	LipopolysaccharidesIBA 01/2017

Therapy/Procedure

8	Therapeutics 03/2024 - 03/2008
3	Immunotherapy 07/2016 - 01/2006
2	Liver Transplantation 01/2014 - 11/2013
1	Lasers (Laser) 12/2022
1	Injections 01/2019